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Early observational data and clinical experience suggest GLP-1s do not typically trigger or exacerbate ulcerative colitis flares, though individual gut microbiome composition and disease severity may influence tolerability and symptom response

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While a role in cellular stress response is emerging, the cellular targets of GSTO1 and its functions have not been fully understood

Some research has found that these meds may be associated with gastroparesis (stomach paralysis) and bowel obstruction